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Synergistic optimization framework for the process synthesis and design of biorefineries

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 251-273 doi: 10.1007/s11705-021-2071-9

Abstract: The conceptual process design of novel bioprocesses in biorefinery setups is an important task, whichdetermine candidate process topologies and simulation-based optimization to consolidate the process design

Keywords： biotechnology     surrogate modelling     superstructure optimization     simulation-based optimization     process design    

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Design and synthesis of ZnCoO/CdS for substantially improved photocatalytic hydrogen production

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 5,   Pages 606-616 doi: 10.1007/s11705-022-2233-4

Abstract: This design can provide reference for developing high-efficiency photocatalysts.

Keywords： ZnCo2O4 nanosphere     CdS nanorods     photocatalytic hydrogen evolution    

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Dimensional synthesis of a novel 5-DOF reconfigurable hybrid perfusion manipulator for large-scale spherical

Hui YANG, Hairong FANG, Yuefa FANG, Xiangyun LI

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 1,   Pages 46-60 doi: 10.1007/s11465-020-0606-2

Abstract: This study mainly presents the dimensional synthesis of the proposed HPM.With the genetic algorithm, dimensional synthesis is conducted by minimizing GCOF subject to the given

Keywords： 5-DOF hybrid manipulator     reconfigurable base     large workspace     dimensional synthesis     optimal design    

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Structural synthesis of ancient Chinese foot-operated silk-reeling mechanism

Kuohung HSIAO, Yuhsun CHEN, Hongsen YAN,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3,   Pages 279-288 doi: 10.1007/s11465-010-0101-2

Abstract: Based on the analysis of the mechanism, the structural characteristics and design constraints of theThen, according to the concepts of generalization and specialization subject to the concluded design

Keywords： silk-reeling mechanism     structure of mechanism     reconstruction design     history of machinery    

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Process synthesis with simultaneous consideration of inherent safety-inherent risk footprint

Andreja Nemet, Jiří J. Klemeš, Zdravko Kravanja

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 4,   Pages 745-762 doi: 10.1007/s11705-018-1779-7

Abstract: Inherent safety can effectively be enhanced in the early stages of the design, when the main decisionson process design are made.A mixed-integer, nonlinear programming (MINLP) model was used for the synthesis of a methanol productionprocess, considering risk assessment during the synthesis.Risk assessment is performed simultaneously with the MINLP process synthesis, where the risk is determined

Keywords： inherent safety     process design     simultaneous risk assessment     risk footprint     methanol process    

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Design of a novel side-mounted leg mechanism with high flexibility for a multi-mission quadruped earth

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 2, doi: 10.1007/s11465-022-0740-0

Abstract: At present, few methods for these robots’ leg design utilize a side-mounted spatial parallel mechanismThus, this paper presents a complete design process of a novel 5-degree-of-freedom (5-DOF) hybrid legWith regard to the synthesis method of the parallel mechanism, a family of concise hybrid leg mechanisms

Keywords： design synthesis     parallel mechanism     hybrid leg mechanism     screw theory     quadruped robot    

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Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 231-237 doi: 10.1007/s11705-010-1022-7

Abstract: A series of 2-aryl-3-(4,5,6-trimethylpyrimidin-2-yl) thiazolidin-4-ones ( – ) and their derivatives bearing a lipophilic substituent, like acetoxy group ( – ), propionyloxy group ( – ), methyl ( and ) at C-5 on thiazolidin-4-one ring were designed, synthesized and evaluated for their HIV-RT inhibitory activity. Using self-catalyzed Pummerer reaction, compounds – and – were obtained in good yield (63.1% 75.2%). Preliminary anti-HIV-RT test of these derivatives indicated that compounds – , (propionyloxy group at C-5) showed moderate HIV-RT inhibitory activity and compounds and with methyl at C-5 showed a weak HIV-RT inhibitory activity. Structure activity relationship analysis suggested that the substituted groups on C-5 would be unfavorable to anti-HIV-RT activity and that the steric effect might play a critical role in the anti-HIV RT activity.

Keywords： 5-subsituted thiazolidin-4-ones     Pummerer reaction     anti-HIV-RT activity     SARs    

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Design and analysis of the gripper mechanism based on generalized parallel mechanisms with configurable

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 4,   Pages 765-781 doi: 10.1007/s11465-021-0655-1

Abstract: Generalized parallel mechanisms with a configurable moving platform have become popular in the research field of parallel mechanism. This type of gripper mechanism can be applied to grasp large or heavy objects in different environments that are dangerous and complex for humans. This study proposes a family of novel (5 + 1) degrees of freedom (three translations and two rotations plus an additional grasping motion) gripper mechanisms based on the generalized parallel mechanisms with a configurable moving platform. First, the configurable moving platform, which is a closed loop, is designed for grasping manipulation. The hybrid topological arrangement is determined to improve the stiffness of the manipulator and realize high load-to-weight ratios. A sufficient rule based on Lie group theory is proposed to synthesize the mechanism. The hybrid limb structure is also enumerated. A family of novel gripper mechanisms can be assembled through the hybrid limbs by satisfying the rule. Two examples of the gripper mechanisms with and without parallelogram pairs are shown in this study. A kinematic analysis of the example mechanism is presented. The workspace shows that the mechanism possesses high rotational capability. In addition, a stiffness analysis is performed.

Keywords： generalized parallel mechanism     configurable moving platform     gripper mechanism     type synthesis     kinematic    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing

Xiaoming Ding, Zhiwen Zhai, Luping Lv, Zhaohui Sun, Xinghai Liu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 379-386 doi: 10.1007/s11705-017-1634-2

Abstract: A variety of pyrazole derivatives containing 1,3,4-thiadiazole moiety were synthesized under microwave irradiation, and their structures were confirmed by H NMR and HRMS. They were evaluated for herbicidal and antifungal activities, and the results indicated that two compounds with a phenyl group ( ) and 4- -butylphenyl group ( ) possess good herbicidal activity for dicotyledon and with the inhibition of 90% for root and 80%–90% for stalk at 100 ppm respectively. The structure-activity relationship of compounds and was also studied by density function theory method.

Keywords： pyrazole     1     3     4-thiadiazole     antifungal activity     herbicidal activity     density function theory    

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Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 4,   Pages 579-594 doi: 10.1007/s11705-018-1770-3

Abstract: The room temperature synthesis of ZIF-8 micro- and nano-particles was investigated using a mixed methanol-waterResponse surface methodology was used to determine the effect of the synthesis conditions on the ZIF-solvents with different strengths in producing ZIF-8 crystals is a practical method to size-controlled synthesisThis method is more favorable for industrial-scale ZIF-8 synthesis than using excess amounts of ligands

Keywords： metal organic frameworks     zeolitic imidazolate frameworks     ZIF-8     response surface methodology     Box Behnken design    

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Automated synthesis of steady-state continuous processes using reinforcement learning

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 288-302 doi: 10.1007/s11705-021-2055-9

Abstract: Automated flowsheet synthesis is an important field in computer-aided process engineering.The present work demonstrates how reinforcement learning can be used for automated flowsheet synthesiswithout any heuristics or prior knowledge of conceptual design.Therein, flowsheet synthesis is modelled as a game of two competing players.

Keywords： automated process synthesis     flowsheet synthesis     artificial intelligence     machine learning     reinforcement    

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An efficient technique for improving methanol yield using dual CO

Yang Su, Liping Lü, Weifeng Shen, Shun’an Wei

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 4,   Pages 614-628 doi: 10.1007/s11705-019-1849-5

Abstract: Abstract Steam methane reforming (SMR)-based methanol synthesis plants utilizing a single CO2 feed representapproach in which captured CO2 is introduced into both the SMR process and the recycle gas of the methanol synthesis

Keywords： methanol synthesis     CO2 utilization     dry methane reforming     steam methane reforming     process design    

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Design, Synthesis, and Biological Activity of Novel Aromatic Amide Derivatives Containing Sulfide and Article

Xuewen Hua, Nannan Liu, Sha Zhou, Leilei Zhang, Hao Yin, Guiqing Wang, Zhijin Fan, Yi Ma

Engineering 2020, Volume 6, Issue 5,   Pages 553-559 doi: 10.1016/j.eng.2019.09.011

Abstract: rate, and a molecular docking simulation was performed that can provide important guidance for the design

Keywords： Synthesis     Nematicidal activity     Fungicidal activity     Molecular docking    

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Effect of potassium carbonate on catalytic synthesis of calcium carbide at moderate temperature

Dejun SHI, Ke QIAO, Zifeng YAN

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 3,   Pages 372-375 doi: 10.1007/s11705-010-0570-1

Abstract: This result confirmed the catalytic effect of potassium carbonate on the synthesis of calcium carbide

Keywords： calcium carbide     synthesis     catalysis    

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Title Author Date Type Operation

Synergistic optimization framework for the process synthesis and design of biorefineries

Journal Article

Design and synthesis of ZnCoO/CdS for substantially improved photocatalytic hydrogen production

Journal Article

Dimensional synthesis of a novel 5-DOF reconfigurable hybrid perfusion manipulator for large-scale spherical

Hui YANG, Hairong FANG, Yuefa FANG, Xiangyun LI

Journal Article

Structural synthesis of ancient Chinese foot-operated silk-reeling mechanism

Kuohung HSIAO, Yuhsun CHEN, Hongsen YAN,

Journal Article

Process synthesis with simultaneous consideration of inherent safety-inherent risk footprint

Andreja Nemet, Jiří J. Klemeš, Zdravko Kravanja

Journal Article

Design of a novel side-mounted leg mechanism with high flexibility for a multi-mission quadruped earth

Journal Article

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Journal Article

Design and analysis of the gripper mechanism based on generalized parallel mechanisms with configurable

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing

Xiaoming Ding, Zhiwen Zhai, Luping Lv, Zhaohui Sun, Xinghai Liu

Journal Article

Parametric study on the mixed solvent synthesis of ZIF-8 nano- and micro-particles for CO adsorption:

Alireza Hadi, Javad Karimi-Sabet, Abolfazl Dastbaz

Journal Article

Automated synthesis of steady-state continuous processes using reinforcement learning

Journal Article

An efficient technique for improving methanol yield using dual CO

Yang Su, Liping Lü, Weifeng Shen, Shun’an Wei

Journal Article

Design, Synthesis, and Biological Activity of Novel Aromatic Amide Derivatives Containing Sulfide and

Xuewen Hua, Nannan Liu, Sha Zhou, Leilei Zhang, Hao Yin, Guiqing Wang, Zhijin Fan, Yi Ma

Journal Article

Effect of potassium carbonate on catalytic synthesis of calcium carbide at moderate temperature

Dejun SHI, Ke QIAO, Zifeng YAN

Journal Article